The "little round friends" seem to be pills, taken every morning at 8:00. The clues are the "yellow and chalky faces" and the "daily meetings," which the speaker treats like a ritual. The speaker defends them against unnamed people who blame the pills whenever the speaker cries, shouts, or goes blank. Each time, the answer is the same: they don't make me feel this way.
The tone is childlike and singsong, with simple rhymes and a repeated refrain. That lightness hides something more serious. The speaker sounds tired of being second-guessed and wants the medication to be seen as help, not harm. Calling the pills "friends" suggests they offer a kind of loyalty that people don't.
The ending hits hardest. After all the praise, the poem turns on "you know who won't love?" and answers with the blunt, isolated line "everyone else." The mood shifts from playful defiance to quiet loneliness, leaving the reader with the sense that the speaker feels misunderstood.