The speaker is admitting to a mess. "I've broken a lot of things" is blunt, and the next line shows how tempting it is to excuse that damage by pointing at "this dis-ease." The hyphenated spelling makes us read the word two ways: as an illness, and as a lack of ease, a constant discomfort. The speaker seems to know that blaming it is convenient, and wishes to be "honest with me," which suggests the first person they have been dodging is themselves.
The refrain, "Honey, I've gone to pot," is wry and a little desperate. It sounds like an apology to a partner, delivered with a joking phrase that hides real shame. "On my knees" can suggest being humbled, or even begging, and the poem hints that someone else has played a part in that. The last line, "Trying to cure this dis-ease," is quiet and unresolved. The mood is weary, rueful and raw, with humor used as a shield.