The speaker describes a crowd of "creatures" and pairs each one with a contrasting pair of eyes: big bodies with small eyes, cold bodies with happy eyes, warm bodies with dead ones. The pattern keeps showing that what people look like on the outside doesn't match what shows in their gaze. The "creatures" seem to be other people, and the speaker finds them strange, mismatched and a little unsettling.
The last lines turn personal. Everyone is looking at the speaker, but nobody truly sees them. That is where the poem's loneliness comes from. The speaker is watched and surrounded, yet still unnoticed in any real sense. The short, repeated lines feel like a list the speaker has been keeping for a long time, and the mood is tired, detached and quietly sad. The question about who can be "this cold and heated" suggests confusion about how people can hold such opposites at once. The title, "Eyes in Denial," hints that the refusal to see may be deliberate.