Anyone who has lain awake in the middle of the night will recognize the scene here. The speaker is up at two in the morning, and the word "again" in both the title and the first line tells us this isn't a one-off. It's a pattern, and the speaker is worn down by it.
The poem lists physical symptoms one after another: a racing, aching heart, a cloudy head, shaking hands, sore eyes. The speaker never names the feeling, though the body suggests anxiety or panic. The lines are short and plain, which makes them feel breathless, like a person who can only report what's happening rather than explain it.
The final question, "When will this ever stop?", is the only moment where the speaker steps back from the symptoms and asks for relief. It gets no answer. The mood is exhausted, tense and quietly desperate, and the poem ends with that uncertainty still hanging.